Application of meso-hydrobenzoin-derived chiral auxiliaries for the stereoselective synthesis of highly substituted pyrrolidines by 1,3-dipolar cycloaddition of azomethine ylides

作者：Bica Katharina; Gaertner Peter^*

来源：Tetrahedron: Asymmetry , 2010, 21(6): 641-646.

DOI：10.1016/j.tetasy.2010.04.010

The metal-catalyzed stereoselective 1,3-dipolar cycloaddition of azomethine ylides and acrylates using recyclable meso-hydrobenzoin-derived chiral auxiliaries is described. Cleavage of the auxiliary leads to highly substituted pyrrolidines in up to 87% enantiomeric excess.

• 出版日期2010-4-8