New Family of Peptidomimetics Based on the Imidazole Motif

作者:Petit Sylvain; Fruit Corinne; Bischoff Laurent*
来源:Organic Letters, 2010, 12(21): 4928-4931.
DOI:10.1021/ol102118u

摘要

Starting from amino acid esters, new peptidomimetics based on the imidazole scaffold were prepared. An efficient and rapid sequence consisting of two subsequent one-pot procedures was developed and applied to various aminoacids. As they provide more substitution patterns, these heterocyclic mimics are promising tools for structural and biological studies.

  • 出版日期2010-11-5