Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles

作者：Simon Diana^*; Garcia Garcia Esther; Royo Felix; Manuel Falcon Perez Juan; Avila Jesus

来源：FEBS LETTERS, 2012, 586(1): 47-54.

DOI：10.1016/j.febslet.2011.11.022

• Tau protein
• Alzheimer%26apos
• s disease
• Membrane vesicles

Increasing amounts of tau protein were expressed in non-neuronal cells. When intracellular amounts reached a threshold level, tau protein was released to the extracellular culture medium in association with membrane vesicles. Hence, we propose that tau might be secreted through membrane vesicles as a cellular mechanism to eliminate the excess of tau protein, thereby avoiding its toxicity.

• 出版日期2012-1-2