Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development

作者：Wang Yongmei; Bikle Daniel D; Chang Wenhan^*

来源：Bone Research, 2013, 1(3): 249-259.

DOI：10.4248/BR201303003

• IGF-I
• IGF-IR
• signaling
• chondrocyte
• osteoblast
• osteoclast
• GH
• PTH
• CaSR
• Calcium-sensing receptor
• cell-cell communication

Insulin-like growth factor-I (IGF-I) regulates cell growth, survival, and differentiation by acting on the IGF-I receptor, (IGF-IR)-a tyrosine kinase receptor, which elicits diverse intracellular signaling responses. All skeletal cells express IGF-I and IGF-IR. Recent studies using tissue/cell-specific gene knockout mouse models and cell culture techniques have clearly demonstrated that locally produced IGF-I is more critical than the systemic IGF-I in supporting embryonic and postnatal skeletal development and bone remodeling. Local IGF-I/IGF-IR signaling promotes the growth, survival and differentiation of chondrocytes and osteo-blasts, directly and indirectly, by altering other autocrine/paracrine signaling pathways in cartilage and bone, and by enhancing interactions among these skeletal cells through hormonal and physical means. Moreover, local IGF-I/IGF-IR signaling is critical for the anabolic bone actions of growth hormone and parathyroid hormone. Herein, we review evidence supporting the actions of local IGF-I/IGF-IR in the above aspects of skeletal development and remodeling.

• 出版日期2013-9-25