Differential Signaling Circuits in Regulation of Ultraviolet C Light-induced Early- and Late-phase Activation of NF-kappa B

作者：Wu Shiyong^*; Tong Lingying

来源：Photochemistry and Photobiology, 2010, 86(5): 995-999.

DOI：10.1111/j.1751-1097.2010.00767.x

Ultraviolet C light (UVC) induces nuclear factor-kappa B (NF-kappa B) activation via a complex network. In the early phase (4-12 h) of irradiation, NF-kappa B activation is accompanied with I kappa B alpha reduction via a translation inhibition pathway. In the late phase of UVC-induced NF-kappa B activation (16-24 h), the I kappa B alpha depletion is a combined result of regulation at both transcriptional and translational levels. However, the NF-kappa B activation appears to be independent of the level of I kappa B alpha. In this review, we will discuss the multiple signaling circuits that regulate NF-kappa B activation during the early and late phases of UVC irradiation.

• 出版日期2010-10