Binding site residues in beta-lactamases: role in non-classical interactions and metal binding

作者：Lavanya P; Ramaiah Sudha; Anbarasu Anand^*

来源：Journal of Coordination Chemistry, 2014, 67(17): 2898-2910.

DOI：10.1080/00958972.2014.956661

• Non-classical interactions
• Protein functional site
• beta-Lactamase
• Metal-coordinating residues
• Hydrophobicity

Proteins bind with one or more metal ions in their native state to facilitate the biological function of the protein. The study of critical interactions between the biological molecules and metals is an important field of study. In this work, we focus on the functional specificity of residues coordinating with the metals commonly found in beta-lactamases, Zn, Mg, Na, Cu, Mn, Ni, Fe, K, and Cd through non-classical interactions. All the residues located in the metal-binding site of beta-lactamases are involved in non-classical interactions. The data obtained from this study will be useful to understand the functional role of metal-coordinating residues in the specificity of beta-lactamases, thus offering promising strategy to design effective beta-lactamase inhibitors.

• 出版日期2014-9-2