Non-Invasive Evaluation of Heart Function with Four-Dimensional Echocardiography

作者：Chen, Ran; Zhu, Meihua; Sahn, David J.; Ashraf, Muhammad^*

来源：PLos One, 2016, 11(5): e0154996.

DOI：10.1371/journal.pone.0154996

• SPECKLE-TRACKING ECHOCARDIOGRAPHY
• GLOBAL LONGITUDINAL STRAIN
• LEFT-VENTRICULAR FUNCTION
• TIME 3-DIMENSIONAL ECHOCARDIOGRAPHY
• REGIONAL MYOCARDIAL-FUNCTION
• DOPPLER-ECHOCARDIOGRAPHY
• FAILURE
• DEFORMATION
• INFARCTION
• REPERFUSION

Background @@@ The aim of this study is to assess the accuracy and feasibility of left ventricular systolic function determined by four-dimensional echocardiography (4DE). @@@ Methods @@@ Latex balloons were sewn into the left ventricle (LV) of 20 freshly harvested pig hearts which were then passively driven by a pulsatile pump apparatus. Global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS) and left ventricular ejection fraction (LVEF) derived from 4DE and two-dimensional echocardiography (2DE)derived LVEF were quantified at different stroke volumes (SV) 30-70 ml and correlated with sonomicrometry data. @@@ Results @@@ In all comparisons, GLS, GCS, GAS, 2DE-LVEF, and 4DE-LVEF demonstrated strong correlations with sonomicrometry data (r = 0.77, r = 0.89, r = 0.79, r = 0.93, r = 0.96, all P < 0.001). Bland-Altman analyses showed slight overestimations of echo-derived GLS, GCS, 2DE-LVEF and 3DE-LVEF over sonomicrometry values (bias = 2.88, bias = 3.99, bias = 3.37, bias = 2.78, respectively). Furthermore, there is better agreement between GCS, 4D LVEF and sonomicrometry values compared with GLS and 2D LVEF. @@@ Conclusion @@@ Four-dimensional echocardiography accurately assesses LV function. GCS derived by 4DE is a potential alternative parameter to quantify LV systolic function.

• 出版日期2016-5-4
• 单位浙江大学