Artemisinin concentration and antioxidant capacity of Artemisia annua distillation byproduct

作者：Ferreira Jorge F S; Zheljazkov Valtcho D^*; Gonzalez Javier M

来源：Industrial Crops and Products, 2013, 41: 294-298.

DOI：10.1016/j.indcrop.2012.05.005

• Artemisinin
• Essential oil yield
• Steam distillation
• Distillation byproduct
• Pressurized liquid extraction
• Accelerated solvent extraction
• Hot water extraction
• Artemisinin water solubility

Artemisia annua is mostly known as the source of artemisinin, the raw material for the production of artemisinin-based combination therapy, used against drug-resistant Plasmodium falciparum where malaria is endemic. Artemisinin is also effective against helminthic and protozoan parasites that afflict both humans and livestock. Besides being the only commercial source of artemisinin, the plant contains a pleasantly aromatic essential oil valued in perfumery and cosmetics. However, multi-use of the leaf biomass for the production of artemisinin, essential oil, and antioxidants has never been investigated. The objectives of this research were to evaluate the effect of distillation time of A. annua biomass on essential oil yield, artemisinin concentration, and antioxidant capacity of the plant residue from distillation (PRD). Results demonstrated that leaf biomass can be explored for both essential oil and as a source of antioxidants, but the PRD is devoid of artemisinin. The high antioxidant capacity of the PRD (75% of the control samples) suggests that the industrial byproduct used to produce the essential oil is also a potential source of antioxidants for use as a livestock feed supplement or as a source of compounds for the nutraceuticals market.

• 出版日期2013-1