科研之友
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摘要
A highly stereoselective synthesis of functionalized 3,3'-pyrrolidinyl-dispirooxindole derivatives with three stereogenic centers, including two contiguous spiro-stereocenters, has been achieved through an organocatalytic Mannich/Boc-deprotection/aza-Michael sequence. Employing the commercially available (DHQD)(2)PHAL as the catalyst, the scalable reaction occurs with good yields and excellent stereo-selectivities, providing a short entry into a series of 3,3'-pyrrolidinyl-dispirooxindoles of potentially medical value.
- 出版日期2016
