Potent In Vitro Antibacterial Activity of DS-8587, a Novel Broad-Spectrum Quinolone, against Acinetobacter baumannii

作者：Higuchi Saito^*; Onodera Yoshikuni; Chiba Megumi; Hoshino Kazuki; Gotoh Naomasa

来源：Antimicrobial Agents and Chemotherapy, 2013, 57(4): 1978-1981.

DOI：10.1128/AAC.02374-12

We investigated the in vitro activity of DS-8587, a novel fluoroquinolone, against Acinetobacter baumannii. The MICs of DS-8587 against clinical isolates and its inhibitory activity against target enzymes were superior to those of ciprofloxacin and levofloxacin. Furthermore, the antibacterial activity of DS-8587 was less affected by adeA/adeB/adeC or abeM efflux pumps than was that of ciprofloxacin and the frequency of single-step mutations with DS-8587 was lower than that with ciprofloxacin. DS-8587 might be an effective agent against A. baumannii infection.

• 出版日期2013-4