Association study of integrins beta 1 and beta 2 gene polymorphism and papillary thyroid cancer

作者：Eun Young Gyu; Kim Su Kang; Chung Joo Ho; Kwon Kee Hwan^*

来源：American Journal of Surgery, 2013, 205(6): 631-635.

DOI：10.1016/j.amjsurg.2012.05.035

• Papillary thyroid cancer
• Integrin
• Polymorphism

BACKGROUND: We investigated whether single nucleotide polymorphisms (SNPs) of integrin beta 1 (ITGB1) and integrin beta 2 (ITGB2) contribute to the development of papillary thyroid cancer (PTC).
METHODS: Two synonymous SNPs (rs2230396 and rs2298141) of ITGB1 and 1 synonymous SNP (rs2352326), 1 5' URT-region SNP (rs2070947), and 1 promoter SNP (rs2070946) of ITGB2 SNPs were genotyped using direct sequencing in 94 patients with PTC and 213 healthy controls. Genetic data were analyzed using SNPStats (http://bioinfo.iconcologia.net/SNPstats), Helix Tree (Golden Helix Inc, Bozeman, MT), and SNPAnalyzer (ISTECH Corp, Goyang City, Republic of Korea).
RESULTS: The promoter SNP (rs2070946) of ITGB2 was significantly associated with the development of PTC (dominant model, log-additive model). The G allele frequencies of the promoter SNP (rs2070946) of ITBG2 in patients with PTC (19.9%) were increased by about 2-fold compared with controls (10.2%).
CONCLUSIONS: Our results suggest that a promoter SNP (rs2070946) of ITGB2 might be associated with a risk of PTC.

• 出版日期2013-6