A New Powerful Strategy for the Organocatalytic Asymmetric Construction of a Quaternary Carbon Stereogenic Center

作者：Inokoishi Yogo; Sasakura Niiha; Nakano Keiji; Ichikawa Yoshiyasu; Kotsuki Hiyoshizo^*

来源：Organic Letters, 2010, 12(7): 1616-1619.

DOI：10.1021/ol100350w

A new method for chiral diamine-catalyzed Robinson-type annulation was developed to construct cyclohexenone derivatives bearing a quaternary carbon stereogenic center at the 4-position In high enantiomeric excess. This method was successfully applied to the short synthesis of (+)-sporochnol A.

• 出版日期2010-4-2