Antimicrobial and Cytotoxic Evaluation of New Quinazoline Derivatives

作者：Turan Zitouni Gulhan; Yurttas Leyla; Saka Guner; Canturk Zerrin; Gencer Hulya Karaca; Baysal Merve; Kaplancikh Zafer Asim^*

来源：Natural Product Communications, 2016, 11(11): 1645-1648.

DOI：10.1177/1934578x1601101105

• Quinazoline
• Antimicrobial activity
• Cytotoxicity
• Hydrazone

The synthesis of nine new quinazoline derivatives (2a-21) and evaluation of their antimicrobial and cytotoxic activities were aims of the present work. For the synthesis of the compounds, 2-chloro-6,7-dimethoxyquinazolin-4-amine was used as the initial starting material. The intermediate product, 2-hydrazinyl-6,7-dimethoxyquinazolin-4-amine, was reacted with appropriate aromatic aldehydes to obtain 2-(2-benzylidenehydrazinyl)-6,7-dimethoxyquinazolin-4-amine derivatives as final compounds. The structures of the compounds were elucidated by and C-13-NMR, IR, and MS analyses. The new pure compounds were evaluated for their potential antimicrobial and cytotoxic activities using in vitro microdilution and cell culture techniques, respectively. The compounds 2e and 2f may be promising candidates for the treatment of fungal infections with their activity and cytotoxicity.

• 出版日期2016-11