An Efficient Deprotection of N-Trimethylsilylethoxymethyl (SEM) Groups From Dinucleosides and Dinucleotides

作者：Chandra Tilak; Broderick William E; Broderick Joan B^*

来源：Nucleosides Nucleotides & Nucleic Acids, 2010, 29(2): 132-143.

DOI：10.1080/15257771003612847

• SAM
• S-adenosylmethionine
• SPL
• spore photoproduct lyase
• SP
• spore photoproduct
• TES
• triethylsilyl
• TBDMS
• tert-butyldimethylsilyl

A convenient and efficient method for deprotection of N-(trimethyl)silylethoxymethyl (SEM) groups from thymidine dinucleoside and dinucleotide has been achieved. The SEM groups were easily removed in excellent yields from protected nucleosides, dinucleosides, and dinucleotides.

• 出版日期2010