Association of biochemical hyperandrogenism with type 2 diabetes and obesity in Chinese women with polycystic ovary syndrome

作者：Zhao, Xiaomiao; Zhong, Junmin; Mo, Yaqin; Chen, Xiaoli; Chen, Yaxiao; Yang, Dongzi^*

来源：International Journal of Gynecology & Obstetrics, 2010, 108(2): 148-151.

DOI：10.1016/j.ijgo.2009.09.021

• Hirsutism
• Hyperandrogenemia
• Polycystic ovary syndrome
• Obesity
• Type 2 diabetes

Objective: To evaluate the effect of hyperandrogenism on metabolic disorders among patients with polycystic ovary syndrome (PCOS) diagnosed using the Rotterdam criteria. Methods: A retrospective analysis of the clinical records of 883 women with KOS and 717 premenopausal controls identified from the general population. Results: A total of 686 (77.7%) patients were classified with PCOS based on National Institutes of Health (NIH) criteria, and 164 out of 197 (83.2%) additional patients had no hyperandrogenism. Women with normal androgen levels exhibited lower frequencies of obesity, type 2 diabetes, acanthosis nigricans, genetic history of diabetes, and elevated Matsuda index compared with hyperandrogenic patients. Hyperandrogenemia, but not hirsutism, was independently associated with the risk for type 2 diabetes (odds ratio [OR] 5.7; P=0.028) and obesity (OR 1.7; P = 0.005) among Chinese patients with PCOS. Conclusions: Hyperandrogenemia is associated with type 2 diabetes and obesity in Chinese women with PCOS and should be considered at first-line management of hyperandrogenism and infertility due to PCOS.

• 出版日期2010-2
• 单位中山大学