Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice

作者：Xin Yongning; Li Wei; Lu Linlin; Zhou Li; Victor, David W.; Xuan Shiying^*

来源：Journal of Ocean University of China, 2016, 15(4): 719-725.

DOI：10.1007/s11802-016-3124-4

• Stichopus japonicus acid mucopolysaccharide
• hepatitis B virus
• transgenic mice
• antiviral

Hepatitis B virus (HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka (SJAMP) could inhibit HBsAg and HBeAg expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP (30 mg kg(-1)), middle dose SJAMP (40 mg kg(-1)), high dose SJAMP (50 mg kg(-1)) and IFN (45 IU kg(-1)) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBsAg and HBcAg levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.

• 出版日期2016-8
• 单位青岛市市立医院