Differentiation and function of pro-inflammatory Th17 cells

作者：Dong Chen^*

来源：Microbes and Infection, 2009, 11(5): 584-588.

DOI：10.1016/j.micinf.2009.04.001

• Helper T cells
• Cytokines
• Inflammation
• Autoimmunity

After activation, CD4 helper T (Th) cells differentiate into cytokine-secreting effector subsets. A novel subset of CD4 helper T (Th) cells that produce two related cytokines IL-17 and IL-17F has been recently identified and shown to play critical function in inflammation and autoimmunity. Here I summarize recent work by us as well as other investigators in understanding the transcriptional regulation of Th17-cell differentiation, their developmental relationship with regulatory T cells and the function of IL-17 and IL-17F in vivo.

• 出版日期2009-4