Association of pneumococcal conjugate vaccination with rates of ventilation tube insertion in Denmark: population-based register study

作者：Groth Christina^*; Thomsen Reimar W; Ovesen Therese

来源：BMJ Open, 2015, 5(6): e007151.

DOI：10.1136/bmjopen-2014-007151

Objective: To examine if the introduction of pneumococcal conjugate vaccine (PCV) in Denmark was associated with a decrease in the rate of ventilation tube (VT) insertions performed by office-based practising ear, nose and throat (ENT) specialists.
Design: Population-based register study based on prospectively collected data.
Setting: Central Denmark Region. Data on VT insertions performed by any office-based practising ENT specialist in the region were collected from the National Health Service Registry.
Participants: All children below the age of 2 years with a first-time VT insertion from 2001 through 2011.
Main outcome measures: Age-stratified and gender-stratified standardised incidence rates of first-time VT insertion, and incidence rate ratio for PCV period 2008-2011 compared with pre-PCV period 2001-2007.
Results: The annual incidence rate of first-time VT insertion in small children increased steadily from 64/1000 person-years in 2001 to 100/1000 person-years in 2011. The incidence rate ratio was 1.27 (95% CI 1.24 to 1.30) in the PCV period compared with the pre-PCV period.
Conclusions: The introduction of PCV into the Danish childhood immunisation programme in 2007 was not associated with a subsequent decrease in the rate of VT insertions among children below the age of 2 years. Instead, the rate continued to rise, as before the introduction of PCV.

• 出版日期2015