Analysis of serum corticosteroid-induced alkaline phosphatase isoenzyme in dogs with hepatobiliary diseases

作者：Kojima K; Ohno K^*; Kanemoto H; Goto Koshino Y; Fukushima K; Tsujimoto H

来源：Journal of Small Animal Practice, 2017, 58(5): 257-262.

DOI：10.1111/jsap.12623

OBJECTIVE : To reveal the relationship between canine corticosteroid-induced alkaline phosphatase isoenzyme activity and hepatobiliary diseases.
MATERIALS AND METHODS : Retrospective analysis of the relationship between serum corticosteroid-induced alkaline phosphatase activity and diagnosis, serum cortisol concentration and alanine transferase activity in dogs with hepatobiliary diseases. Dogs with a history of glucocorticoid administration were excluded.
RESULTS : Seventy-two dogs with hepatobiliary diseases were analysed. The serum corticosteroid-induced alkaline phosphatase concentration was increased in dogs with hepatobiliary diseases. There was no correlation between serum cortisol concentration and serum corticosteroid-induced alkaline phosphatase percentage or activity.
CLINICAL SIGNIFICANCE : Dogs with hepatobiliary disease can exhibit high serum alkaline phosphatase activity even if the dogs have not been administrated glucocorticoids and the serum cortisol concentration is normal.

• 出版日期2017-5