Microbial translocation and T cell activation are not associated in chronic HIV-infected children

作者：Madrid Lola; Noguera Julian Antoni; Falcon Neyra Lola; Fortuny Claudia; De Felipe Beatriz; Torrebadell Montserrat; Sanchez Berta; Valls Anna; Lopez Cortes Luis; Benmarzouk Hidalgo Omar J; Neth Olaf^*

来源：AIDS, 2014, 28(13): 1989-1992.

DOI：10.1097/QAD.0000000000000375

A cross-sectional study of 77 chronic HIV-infected children revealed higher levels of biomarkers of inflammation (ultrasensitive C-reactive protein, D-dimer and beta-2-microglobulin), immune activation (HLA-DR(+)CD38(+)CD4(+) and CD8(+) T cells) and microbial translocation [lipopolysaccaride (LPS), microbial 16S rDNA and sCD14] than 32 healthy controls. Immune activation was higher in viremic children, but microbial translocation occurred independently of viraemia and T cell activation. Our results do not support a relevant role of microbial translocation in T cell activation in chronic HIV-infected children, proposing a need to develop strategies to minimize microbial translocation in the future.

• 出版日期2014-8-24