Apolipoprotein E epsilon 4 Frequency Is Increased among Chinese Patients with Frontotemporal Dementia and Alzheimer%26apos;s Disease

作者：Ji Yong; Liu Mengyuan; Huo Ya Ruth; Liu Shuling; Shi Zhihong; Liu Shuai; Wisniewski Thomas; Wang Jinhuan^*

来源：Dementia and Geriatric Cognitive Disorders, 2013, 36(3-4): 163-170.

DOI：10.1159/000350872

• Alzheimer%26apos
• s disease
• Frontotemporal dementia
• Apolipoprotein E

The relationship between the apolipoprotein E (ApoE) epsilon 4 genotype and an increased risk of developing Alzheimer%26apos;s disease (AD) has been well established in Caucasians but is less established among other ethnicities. ApoE epsilon 4 has also been associated with several other neurological disorders. Whether ApoE epsilon 4 is a risk factor for frontotemporal dementia (FTD) remains controversial. This study examined 432 patients with AD, 62 with FTD, and 381 sex-and age-matched controls. The ApoE epsilon 4 allele frequency was significantly increased among patients in the AD and FTD groups compared with controls. The frequency of the ApoE epsilon 4 allele was 24.86% in late-onset AD (p %26lt; 0.01), 18.02% in early-onset AD (p %26lt; 0.01), 16.13% in FTD (p %26lt; 0.01), and 7.34% in controls. ApoE epsilon 4 prevalence was similar in the FTD and AD groups. The present study suggests that the ApoE epsilon 4 allele is a risk factor for both disorders.

• 出版日期2013
• 单位天津市环湖医院