Accuracy of Diagnostic Methods and Surveillance Sensitivity for Human Enterovirus, South Korea, 1999-2011

作者：Hyeon Ji Yeon; Hwang Seoyeon; Kim Hyejin; Song Jaehyoung; Ahn Jeongbae; Kang Byunghak; Kim Kisoon; Choi Wooyoung; Chung Jae Keun; Kim Cheon Hyun; Cho Kyungsoon; Jee Youngmee; Kim Jonghyun; Kim Kisang; Kim Sun Hee; Kim Min Ji; Cheon Doo Sung^*

来源：Emerging Infectious Diseases, 2013, 19(8): 1268-1275.

DOI：10.3201/eid1908.130496

The epidemiology of enteroviral infection in South Korea during 1999-2011 chronicles nationwide outbreaks and changing detection and subtyping methods used over the 13-year period. Of 14,657 patients whose samples were tested, 4,762 (32.5%) samples were positive for human enterovirus (human EV); as diagnostic methods improved, the rate of positive results increased. A seasonal trend of outbreaks was documented. Genotypes enterovirus 71, echovirus 30, coxsackievirus B5, enterovirus 6, and coxsackievirus B2 were the most common genotypes identified. Accurate test results correlated clinical syndromes to enterovirus genotypes: aseptic meningitis to echovirus 30, enterovirus 6, and coxsackievirus B5; hand, foot and mouth disease to coxsackievirus A16; and hand, foot and mouth disease with neurologic complications to enterovirus 7-1. There are currently no treatments specific to human EV infections; surveillance of enterovirus infections such as this study provides may assist with evaluating the need to research and develop treatments for infections caused by virulent human EV genotypes.

• 出版日期2013-8