A convergent synthesis of the right-hand fragment of ciguatoxin CTX3C

作者：Takamura Hiroyoshi^*; Abe Takashi; Nishiuma Naoki; Fujiwara Rie; Tsukeshiba Takahiko; Kadota Isao

来源：Tetrahedron, 2012, 68(10): 2245-2260.

DOI：10.1016/j.tet.2012.01.071

• Polyether marine natural product
• Ciguatoxin CTX3C
• Convergent synthesis
• Intramolecular allylation

A convergent synthesis of the right-hand fragment of ciguatoxin CTX3C was investigated. The first and second generation stereocontrolled syntheses of the LM ring fragment were achieved via spiroacetalization as a key step, respectively. The polyether framework of the HIJKLM ring fragment was constructed in a convergent manner by using intramolecular allylation, ring-closing metathesis, and stereoselective hydrogenation to form the 36-methyl substituent as the key transformations.

• 出版日期2012-3-11