Short-term Outcome of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Preliminary Analysis of a Multicentre Study

作者：Macri Antonio^*; Arcoraci Vincenzo; Belgrano Valerio; Caldana Marina; Cioppa Tommaso; Costantini Barbara; Cucinotta Eugenio; De Cian Franco; De Iaco Pierandrea; De Manzoni Giovanni; Di Giorgio Angelo; Fleres Francesco; Muffatti Francesca; Orsenigo Elena; Pinna Antonio Daniele; Roviello Franco; Sammartino Paolo; Scambia Giovanni; Saladino Edoardo

来源：Anticancer Research, 2014, 34(10): 5689-5693.

• Cytoreductive surgery
• HIPEC hyperthermia
• morbidity
• mortality

Aim: To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy. Patients and Methods: A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis. Results: In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity. Conclusion: Careful patient selection has to be performed to improve clinical outcomes.

• 出版日期2014-10