Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost

作者：Melillo Elio; Grigoratos Chrysanthos^*; De Sanctis Francesco; Spontoni Paolo; Nuti Marco; Dell'Omodarme Matteo; Ferrari Mauro; Balbarini Alberto

来源：Angiology, 2015, 66(6): 531-538.

DOI：10.1177/0003319714541800

• thromboangiitis obliterans
• buerger disease
• transcutaneous oxygen
• laser doppler
• tobacco
• iloprost

We evaluated the effectiveness of intravenous iloprost (IVI) in outpatients with thromboangiitis obliterans (TAO) and lower limb noninvasive transcutaneous monitoring (TCM) at follow-up (FU). Ten consecutive patients with TAO underwent IVI therapy. Transcutaneous oxygen (TcPo (2)) and carbon dioxide (TcPco (2)) determination and laser Doppler flowmetry (LDF) were performed before and after IVI at 3, 6, and 12 months of FU. Clinical response was positive in 7 patients, whereas 3 nonresponders underwent a second IVI cycle with 1 showing a late positive clinical response. After 12 months of FU, all patients were alive without amputations. Supine and dependent TcP2 levels significantly improved (P < .005). Hallux LDF values showed significant change with the maximal hyperemic test at 44 degrees C (P < .005). Forefoot maximal hyperemic test at 44 degrees C LDF (P < .005) and improved venous arterial reflex (P < .05) showed statistically significant time evolution. We demonstrated some degree of IVI effectiveness and evaluated TCM in patients with TAO.

• 出版日期2015-7