Activation of cell-penetrating peptides by disulfide bridge formation of truncated precursors

作者:Bode Saskia A; Wallbrecher Rike; Brock Roland; van Hest Jan C M; Lowik Dennis W P M*
来源:Chemical communications, 2014, 50(4): 415-417.
DOI:10.1039/c3cc46826g

摘要

A small library of oligoarginine peptides equipped with terminal cysteines was studied with respect to their cell-penetrating properties. The peptides themselves were inactive but gained the ability to enter cells upon extension of their sequence through disulfide bridge formation.

  • 出版日期2014