Assessment of early renal allograft dysfunction with blood oxygenation level-dependent MRI and diffusion-weighted imaging

作者：Park Sung Yoon; Kim Chan Kyo^*; Park Byung Kwan; Kim Sung Ju; Lee Sanghoon; Huh Wooseong

来源：European Journal of Radiology, 2014, 83(12): 2114-2121.

DOI：10.1016/j.ejrad.2014.09.017

• Kidney
• Transplantation
• Blood oxygenation level-dependent MRI
• Diffusion-weighted imaging
• MRI

Purpose: To investigate blood oxygenation level-dependent (BOLD) MRI and diffusion-weighted imaging (DWI) at 3 T for assessment of early renal allograft dysfunction. %26lt;br%26gt;Materials and methods: 34 patients with a renal allograft (early dysfunction, 24; normal, 10) were prospectively enrolled. BOLD MRI and DWI were performed at 3 T. R2* and apparent diffusion coefficient (ADC) values were measured in cortex and medulla of the allografts. Correlation between R2* or ADC values and estimated glomerular filtration rate (eGFR) was investigated. R2* or ADC values were compared among acute rejection (AR), acute tubular necrosis (ATN) and normal function. %26lt;br%26gt;Results: In all renal allografts, cortical or medullary R2* and ADC values were moderately correlated with eGFR (P %26lt; 0.05). Early dysfunction group showed lower R2* and ADC values than normal function group (P %26lt; 0.05). AR or ATN had lower R2* values than normal allografts (P %26lt; 0.05), and ARs had lower cortical ADC values than normal allografts (P %26lt; 0.05). No significant difference of R2* or ADC values was found between AR and ATN (P %26gt; 0.05). %26lt;br%26gt;Conclusion: BOLD MRI and DWI at 3 T may demonstrate early functional state of renal allografts, but may be limited in characterizing a cause of early renal allograft dysfunction. Further studies are needed.

• 出版日期2014-12