An Improved H-Phosphonate Approach for Practical Synthesis of Phosphoramidon

作者：Sun, Qi^*; Yang, Qingkun; Gong, Shanshan; Sun, Jian; Li, Xingjian; Liu, Guodong

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2014, 189(12): 1887-1894.

DOI：10.1080/10426507.2014.902829

• oxidative coupling
• phosphoramidate
• inhibitor constant
• Phosphoramidon
• H-phosphonate

An improved synthetic method based on glycosyl-1-H-phosphonate monoester intermediate has been developed for the multigram-scale preparation of phosphoramidon, a naturally occurring phosphorus-linked glycodipeptide. The inhibitor constant of the synthetic sample against thermolysin established that a high level of biological activity can be obtained following this synthetic method.

• 出版日期2014-12-2
• 单位江西科技师范大学