A facile synthesis of functionalized 7,8-diaza[5]helicenes through an oxidative ring-closure of 1,1'-binaphthalene2,2'-diamines (BINAMs)

作者：Takeda Youhei^*; Okazaki Masato; Maruoka Yoshiaki; Minakata Satoshi

来源：Beilstein Journal of Organic Chemistry, 2015, 11: 1-7.

DOI：10.3762/bjoc.11.2

• aromatic amines
• azahelicenes
• cinnolines
• halogen
• oxidation

A facile and moderately functional-group-tolerant synthetic method for the preparation of 7,8-diaza[5]helicenes has been developed. It comprises of an oxidative ring-closing process of 1,1'-binaphthalene-2,2'-diamine (BINAM) derivatives with a chlorine-containing oxidant (t-BuOCl) in the presence of a base (2,6-lutidine). In addition the basic physicochemical properties of newly synthesized compounds have been investigated.

• 出版日期2015-1-5