Does preserved sphincter of Oddi function prevent common bile duct stones recurrence in patients after endoscopic papillary balloon dilation?

作者：Tsai, Tzung-Jiun; Lin, Chiun-Ku; Lai, Kwok-Hung; Chan, Hoi-Hung^*; Wang, E-Ming; Tsai, Wei-Lun; Cheng, Jin-Shiung; Yu, Hsien-Chung; Chen, Wen-Chi; Hsu, Ping-I

来源：Journal of the Chinese Medical Association, 2018, 81(4): 311-315.

DOI：10.1016/j.jcma.2018.01.007

• Common bile duct stone
• Endoscopic papillary balloon dilation
• Sphincter of Oddi manometry

Background: Whether preserving sphincter of Oddi (SO) function by endoscopic papillary balloon dilation (EPBD) is beneficial for preventing recurrent common bile duct stone disease (CBDS) is controversial. The aim of this study was to measure sphincter of Oddi (SO) function by using SO manometry, and to evaluate the association with recurrent CBDS. @@@ Methods: Patients with suspected CBDS who underwent successful EPBD were included. These patients underwent SO manometry at two months after EPBD with bile duct clearance. They were regularly followed for recurrent CBDS. @@@ Results: From January 2000 to December 2009, 185 patients received EPBD and SO manometry was included. There were 64% male with mean age of 65 +/- 15.6 years. Mean ballooning inflation size was 1.1 +/- 0.19 cm and mean ballooning time was 4.5 +/- 0.85 min 55.7% had a sphincter of Oddi basal pressure (SOBP) of 0 mmHg, 16.2% < 10 mmHg, 26.5% 10-40 mmHg, and 1.6% > 40 mmHg. In multivariate analysis, EPBD with balloon >= 1.2 cm was the only factor for loss of SO function. Moreover, patients with preserved SO function had higher stone recurrence rate (15% vs. 5%, p = 0.034). @@@ Conclusion: EPBD using balloon >= 1.2 cm is a major factor for loss of SO function, which seems to reduce the risk of recurrent CBD stones.

• 出版日期2018-4
• 单位中山大学