A single centre retrospective analysis of AECG classification criteria for primary Sjogren's syndrome based on 112 minor salivary gland biopsies in a Japanese population

作者：Nakamura Hideki^*; Kawakami Atsushi; Iwamoto Naoki; Okada Akitomo; Yamasaki Satoshi; Tamai Mami; Ida Hiroaki; Takagi Yukinori; Hayashi Tomayoshi; Aoyagi Kiyoshi; Nakamura Takashi; Eguchi Katsumi

来源：Rheumatology, 2010, 49(7): 1290-1293.

DOI：10.1093/rheumatology/keq075

• Sjogren's syndrome
• Classification criteria
• Minor salivary gland biopsy

Objective. To assess the usefulness and performance of the American European Consensus Group (AECG) criteria based on minor salivary gland biopsy (MSGB) in Japanese patients with primary SS.
Methods. Among 208 MSGB cases, we retrospectively selected 112 subjects who satisfied the complete set of AECG classification criteria. Of the 112 subjects studied, 63 primary SS patients and 49 non-SS group subjects were classified according to the AECG criteria. The contribution of subjective and objective components was statistically analysed.
Results. Sex, dry eye, Saxon test, Schirmer's test, anti-SSA/Ro antibody, MSGB grading and sialography statistically contributed to the diagnosis. Multiple logistic regression analysis showed that positive MSGB [odds ratio (OR) 105; 95% CI 13, 849), positive anti-SSA/Ro antibody (OR 96; 95% CI 10, 923), a positive Saxon test (OR 46; 95% CI, 6, 340) and the existence of dry eye (OR 8, 95% CI 2, 43) were associated with the diagnosis of primary SS. Among the components of the AECG criteria, MSGB and anti-SSA/Ro antibody were very strong contributors. Furthermore, the abnormal-finding positive rate in sialography significantly correlated with MSGB grading (P-value for trend = 0.0006), although other subjective and objective components were not associated with MSGB grading.
Conclusion. The usefulness of the AECG criteria for Japanese primary SS patients was confirmed.

• 出版日期2010-7