Design, synthesis of some new (2-aminothiazol-4-yl)methylester derivatives as possible antimicrobial and antitubercular agents

作者：Karuvalam Ranjith P; Haridas Karickal R^*; Nayak Susanta K; Row Tayur N Guru; Rajeesh P; Rishikesan R; Kumari N Suchetha

来源：European Journal of Medicinal Chemistry, 2012, 49: 172-182.

DOI：10.1016/j.ejmech.2012.01.008

• Thiazole
• Antibacterial activity
• Antifungal activity
• Antimycobacterial
• X-ray crystallography

A series of (2-aminothiazol-4-yl)methylester (5a-t) derivatives were synthesized in good yields and characterized by H-1 NMR, C-13 NMR, mass spectral and elemental analyses. The crystal structure of 5a was evidenced by X-ray diffraction study. The compounds were evaluated for their preliminary in vitro antibacterial, antifungal activity and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. The synthesized compounds displayed interesting antimicrobial activity.

• 出版日期2012-3