A novel approach for detection and quantification of magnetic nanomarkers using a spin valve GMR-integrated microfluidic sensor

作者：Devkota J; Kokkinis G; Berris T; Jamalieh M; Cardoso S; Cardoso F; Srikanth H; Phan M H; Giouroudi I^*

来源：RSC Advances, 2015, 5(63): 51169-51175.

DOI：10.1039/c5ra09365a

We demonstrate the application of a spin valve giant magneto-resistance (GMR) integrated microfluidic sensor for the detection and quantification of superparamagnetic nanomarkers. A microfluidic channel containing the magnetic fluid, micro-conductors (MCs) for collection of magnetic markers and a spin valve GMR sensor for detecting the presence of magnetic stray field were integrated into a single chip and employed for detection of various concentrations of Nanomag-D beads of 250 nm diameter. The results show that the sensor is capable of detecting concentrations as low as 500 pg mu l(-1) of Nanomag-D beads and quantifying them in a linear scale over a wide particle concentration range (1-500 ng mu l(-1)). Our study provides a novel platform towards the development of a portable lab-on-a-chip sensor.

• 出版日期2015