Neoglycosylation and neoglycorandomization: enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads

作者：Goff Randal D; Thorson Jon S^*

来源：Medchemcomm, 2014, 5(8): 1036-1047.

DOI：10.1039/c4md00117f

This review focuses upon the development, scope, and utility of the highly versatile chemoselective alkoxyamine-based %26apos;neoglycosylation%26apos; reaction first described by Peri and Dumy. The fundamentals of neoglycosylation and the subsequent development of a %26apos;neoglycorandomization%26apos; platform to afford differentially-glycosylated libraries of plant-based natural products, microbial-based natural products, and small molecule-based drugs for drug discovery applications are discussed.

• 出版日期2014-8