Alteration in surface muscle electrical anisotropy in the rat SOD1 model of amyotrophic lateral sclerosis

作者：Li Jia; Rutkove Seward B^*

来源：Clinical Neurophysiology, 2012, 123(1): 206-210.

DOI：10.1016/j.clinph.2011.06.002

• Muscle
• Electrical impedance
• Amyotrophic lateral sclerosis
• Anisotropy
• Rat SOD1 model

Objective: To evaluate the effects of progressive neurogenic change on surface-measured anisotropy via study in the rat superoxide dismutase 1 (SOD1) G93A amyotrophic lateral sclerosis (ALS) model.
Methods: Eight male ALS rats were studied over a period of 10 weeks. In each, the 20 kHz to 1 MHz electrical impedance of the gastrocnemius-soleus complex was measured with electrodes placed at 0 degrees and at 90 degrees relative to the major muscle fiber direction. The major outcome measure, the anisotropy difference (AD) for each of the resistance, reactance, and phase, was calculated as 90-0 degrees values.
Results: All three parameters showed substantial alterations with disease progression. However, the phase AD demonstrated the most substantial change, increasing from 1.8 +/- 1.58 degrees to 10.2 +/- 2.13 degrees (mean +/- standard error) comparing the first and last set of measurements (p = 0.028).
Conclusions: Anisotropy increases substantially with disease progression in the ALS rat.
Significance: Measurement of surface electrical anisotropy offers a non-invasive means for quantifying neurogenic change in muscle.

• 出版日期2012-1