Aerobic Training Increases Expression Levels of SIRT3 and PGC-1 alpha in Skeletal Muscle of Overweight Adolescents Without Change in Caloric Intake

作者：Vargas Ortiz Katya; Perez Vazquez Victoriano; Diaz Cisneros Francisco J; Figueroa Arturo; Jimenez Flores Lizbeth M; Rodriguez DelaRosa Gustavo; Macias Maciste H^*

来源：Pediatric Exercise Science, 2015, 27(2): 177-184.

DOI：10.1123/pes.2014-0112

• health
• body composition
• aerobic
• training

Sirtuin 3 enzyme (SIRT3) is involved in the regulation of mitochondrial energy homeostasis by activating Peroxisome proliferator-activated receptor-gamma coactivator (PGC-1 alpha). Murine models have shown that the protein SIRT3 was modified by exercise and diet, however, the effect of exercise without diet in humans has not been examined. Propose of this paper was to analyze the effect of aerobic training on SIRT3 and PGC-1 alpha in skeletal muscle of overweight adolescents without change in caloric intake. Fourteen overweight or obese male adolescents (15.5 +/- 0.8 years) trained 3 days-week/50 min x session, at 70-80% of maximal heart rate for 12 weeks. Anthropometrics and skeletal muscle biopsies from the vastus lateralis were taken before and after the exercise program to measure adiposity, SIRT3, and PGC-1 alpha proteins. Peak aerobic capacity (VO2peak) was estimated before and after training. The participants did not change their eating habits during the intervention. SIRT3 (1.05 +/- 0.11 vs. 1.25 +/- 0.14 AU, p = .014) and PGC-1a (1.06 +/- 0.15 Vs 1.39 +/- 0.20 AU, p = .009) increased. Fat percentage and waist circumference decreased (p < .05). V-O2peak increased after training (p < .001). There was a significant association between SIRT3 and PGC-1 alpha after training program. These data suggest that aerobic training increased SIRT3 and PGC-1a expression levels in sedentary, overweight, or obese adolescents.

• 出版日期2015-5