Alanine aminotransferase and gamma-glutamyltransferase as markers for elevated insulin resistance-associated metabolic abnormalities in obese Japanese men younger than 30 years of age

作者：Koike Teruhiko^*; Miyamoto Maiko; Oshida Yoshiharu

来源：Obesity Research & Clinical Practice, 2010, 4(1): E73-E79.

DOI：10.1016/j.orcp.2009.09.003

• Insulin resistance
• Obesity
• Liver function test

Objective: This study aimed to understand whether liver function tests predict insulin resistance and its associated metabolic abnormalities in obese young men who are younger than 30 years of age.
Methods: In this cross-sectional study, we determined anthropometric and metabolic parameters and the homeostasis model assessment of insulin resistance (Homa-IR) in 208 obese young Japanese men (age, 18-29 years; BMI +/- SD, 31.3 +/- 3.1 kg/m(2)).
Results: After adjusting for age and BMI, alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were significantly associated with Homa-IR. Both ALT and GGT but not fasting glucose levels had significant positive associations with total cholesterol, LDL, TG, and UA. After adjusting for ALT, GGT remained a significant predictor of total cholesterol, LDL, TG, and UA, but ALT did not remain a significant predictor of these variables after adjusting for GGT.
Conclusion: ALT and GGT have significant associations with insulin resistance and its associated metabolic abnormalities in obese young Japanese men. ALT and GGT may be used as markers of insulin resistance-associated metabolic abnormalities in this cohort.

• 出版日期2010-3