科研之友
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摘要
A practical synthesis of propargylic alcohols was developed by alkynylation of aldehydes mediated by zinc and allyl bromide. Aromatic, aliphatic and vinyl aldehydes react with phenylacetylene or 1-hexyne to obtain various propargylic alcohols at room temperature in up to 98% yield. This method is characterized with inexpensive materials, wide substrate scope, and mild reaction conditions, and is also easy to scale up. In addition, this protocol is applicable to the alkynylation of alpha-ketone esters and epoxides to generate alpha-tertiary-hydroxy esters and alpha-alkynyl alcohols, respectively.
- 出版日期2017-7
- 单位四川大学
