A novel t(4;16)(q25;q23.1) associated with EGF and ELOVL6 deregulation in acute myeloid leukemia

作者：Anelli Luisa; Zagaria Antonella; Coccaro Nicoletta; Tota Giuseppina; Impera Luciana; Minervini Crescenzio Francesco; Pastore Domenico; Minervini Angela; Casieri Paola; Specchia Giorgina; Albano Francesco^*

来源：Gene, 2013, 529(1): 144-147.

DOI：10.1016/j.gene.2013.07.105

• Karyotypic analysis
• Novel chromosomal rearrangements
• Cell proliferation

About 50% of acute myeloid leukemia (AML) patients show the occurrence of non-random chromosome rearrangements. Most of the recurrent karyotypic rearrangements in AML have been defined as distinct disease entities in the 2008 World Health Organization (WHO) classification. In this paper we report an AML case showing a novel t(4:16)(q25;q23.1) rearrangement causing the activation of epidermal growth factor (EGF) and elongation of long-chain fatty acids family member 6 (ELOVL6) genes, rather than the generation of a novel fusion gene.

• 出版日期2013-10-15