A CMOS Amperometric System for Multi-Neurotransmitter Detection

作者：Massicotte Genevieve^*; Carrara Sandro; Di Micheli Giovanni; Sawan Mohamad

来源：IEEE Transactions on Biomedical Circuits and Systems, 2016, 10(3): 731-741.

DOI：10.1109/TBCAS.2015.2490225

• Amperometric readout
• CMOS potentisotat
• electrochemical biosensor
• electrode functionalization
• neurotransmitters detection

In vivo multi-target and selective concentration monitoring of neurotransmitters can help to unravel the brain chemical complex signaling interplay. This paper presents a dedicated integrated potentiostat transducer circuit and its selective electrode interface. A custom 2-electrode time-based potentiostat circuit was fabricated with 0.13 mu m CMOS technology and provides a wide dynamic input current range of 20 pA to 600 nA with 56 mu W, for a minimum sampling frequency of 1.25 kHz. A multi-working electrode chip is functionalized with carbon nanotubes (CNT)-based chemical coatings that offer high sensitivity and selectivity towards electroactive dopamine and non-electroactive glutamate. The prototype was experimentally tested with different concentrations levels of both neurotransmitter types, and results were similar to measurements with a commercially available potentiostat. This paper validates the functionality of the proposed biosensor, and demonstrates its potential for the selective detection of a large number of neurochemicals.

• 出版日期2016-6