科研之友
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摘要
Ethnopharmacological relevance: The roots of Rubio tibetica are chewed as an antidote to anaphylaxis caused by bites of the tick Ornithodoros lahorensis by the Wakhi people in Afghanistan.
Aims of the study: To test whether Rubia tibetica possess anti-histamine effect.
Materials and methods: Water and ethanol extracts of roots of Rubia tibetica were tested for anti-histamine effect on the H-1-receptor in the guinea pig ileum assay. Fixed concentrations of plant extract with increasing concentrations of histamine were examined. Mepyramine was used as control.
Results and conclusion: The ethanol extract of Rubia tibetica showed dose-dependent anti-histamine effect, whereas the water extract had little activity. The chewing of Rubin tibetica roots may alleviate the fatal swelling of the tongue during anaphylaxis.
- 出版日期2012-6-14
