Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

作者：Tng Danny Jian Hang; Hu Rui; Song Peiyi; Roy Indrajit; Yong Ken Tye^*

来源：Micromachines, 2012, 3(4): 615-631.

DOI：10.3390/mi3040615

• MEMS device
• drug delivery
• biomedical applications
• implantable

Despite the advancements made in drug delivery systems over the years, many challenges remain in drug delivery systems for treating chronic diseases at the personalized medicine level. The current urgent need is to develop novel strategies for targeted therapy of chronic diseases. Due to their unique properties, microelectromechanical systems (MEMS) technology has been recently engineered as implantable drug delivery systems for disease therapy. This review examines the challenges faced in implementing implantable MEMS drug delivery systems in vivo and the solutions available to overcome these challenges.

• 出版日期2012-12
• 单位南阳理工学院