Nanospecific Guidance in REACH: A Comparative Physical-Chemical Characterization of 15 Materials with Methodical Correlations

作者：Wohlleben W^*; Ma Hock L; Boyko V; Cox G; Egenolf H; Freiberger H; Hinrichsen B; Hirth S; Lancisiedel R

来源：Journal of Ceramic Science and Technology, 2013, 4(2): 93-104.

DOI：10.4416/JCST2012-00045

• Suspension
• size distribution
• dissolution
• photocatalysis
• regulation

The REACH legislation deals with the Registration, Evaluation, Authorization and Restriction of Chemical substances in Europe. Here we provide a comparative physical-chemical characterization with standardized methods that adhere to the recent REACH guidance for nanomaterials. The suite of materials comprises two pigment-size reference materials, and 13 engineered nanomaterials, thereof four from the OECD sponsorship program. We report for each material on 20 endpoints for physical-chemical properties. Since toxicological effects and occupational exposures have already been reported for several of these materials, our results provide the basis for the exploration of grouping approaches. On the methodical level, our results provide a cross-validation where several methods report the same endpoint. This comparison reveals redundancies in the guidance and allows us to identify the most effective methods.

• 出版日期2013-6