An efficient synthesis of novel benzo[b]pyrido[3 %26apos;,2 %26apos;:4,5]thieno[2,3-e][1,6]naphthy-ridine-8-ones

作者：Wang Dao Lin; Wang Yong Yang; Shi Xiao Ce; Ma Jian

来源：Chinese Chemical Letters, 2015, 26(9): 1109-1112.

DOI：10.1016/j.cclet.2015.05.009

• 4-Bromomethylquinoline-2-one
• 3-Cyanopyridine-2-thione
• Benzo[b]pyrido[3 ',2 ':4,5]thieno[2,3-e][1,6]naphthyridine-8-one
• Thorpe-Ziegler reaction
• Pictet-Spengler reaction

An efficient method for the synthesis of novel benzo[b]pyrido[3'2':4,5] thieno[2,3-e][1,6] naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-(3-aminothieno[2,3-b]pyridin-2-yl)quinoline-2-ones, which could be obtained from the alkylation of 4-bromomethylquinoline-2-ones with 3-cyanopyridine-2-thione followed by a Thorpe-Ziegler isomerization, and aromatic aldehydes under p-TsOH as catalysis in good yields.

• 出版日期2015-9
• 单位渤海大学