Application of charge-transfer complexation for evaluation of the drug-receptor mechanism of interaction: Spectroscopic and structure morphological properties of procaine and pilocarpine complexes with chloranilic acid acceptor

作者：Adam Abdel Majid A^*

来源：Russian Journal of General Chemistry, 2014, 84(6): 1225-1236.

DOI：10.1134/S1070363214060292

• drug-acceptor interaction
• hydrogen bonds
• XRD
• SEM
• surface structure

Study of the charge-transfer or proton-transfer interaction of drugs is important for understanding the drug-receptor interactions and the mechanism of drug action. In the current research the corresponding data were accumulated in the course of synthesis and study of the H-bonded complexes originated from the interaction between procaine (Pro) or pilocarpine (Pil) drugs and chloranilic acid (CLA). The targeted microstructure products have been isolated and characterized by elemental and spectral (electronic and vibrational) data. Microstructural properties of the reported complexes were studied with XRD and SEM techniques. The Pil drug containing complex exhibited a specific electronic spectrum with a strong, broad absorption band with much longer wavelength, lambda(max), than those typical for the individual reagents. It is noteworthy that the complex had good crystallinity. Application of Debye-Scherrer equation indicated that the reported complexes were in the range of nanosize.

• 出版日期2014-6