Age-associated alteration in naive and memory Th17 cell response in humans

作者：Lee Jin Soo; Lee Won Woo; Kim Sang Hyun; Kang Youna; Lee Naeun; Shin Min Sun; Kang Seong Wook; Kang Insoo^*

来源：Clinical Immunology, 2011, 140(1): 84-91.

DOI：10.1016/j.clim.2011.03.018

• Human
• Aging
• IL-17
• T helper 17 (Th17) cells
• CD4+T cells

Th17 cells produce IL-17 that plays an important role in host defense. However, little is known about whether aging affects human Th17 cells. Here we demonstrated that healthy elderly people (age >= 65) had a decreased frequency of IL-17-producing cells in memory CD4(+) T cells compared to healthy young people (age <= 40) while both groups had similar frequencies of IFN-gamma-producing cells in the same memory cell subset as measured by flow cytometry. In contrast, the healthy elderly had increased differentiation of IL-17-producing effector cells but not IFN-gamma-producing cells from naive CD4(+) T cells compared to the healthy young. The results of ELISA also showed similar findings with increased IL-17 production from naive CD4(+) T cells and decreased IL-17 production from memory CD4(+) T cells in the elderly compared to the young. These findings indicate that aging differentially affects naive and memory Th17 cell responses in humans.

• 出版日期2011-7