Angiotensin receptor type 1 polymorphism A1166C is associated with left ventricular remodeling in severe preeclampsia patients and their fetuses

作者：Zhang, Jufang; Qu, Guangdi; Wang, Dongmei; Mu, Yuming^*; Zhu, Qiying^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(10): 14653-14659.

• Angiotensin II type 1 receptor (AT1R)
• gene polymorphism
• A1166C
• preeclampsia
• ventricular remodeling

Objective: To study the correlation of the AT1R gene A1166C polymorphism and left ventricular remodeling in severe preeclampsia patients and their fetuses. Methods: We collected blood from case and control groups and genotyped the samples with the PCR-RFLP technique. We measured the interventricular septum thickness (IVST) in the end diastolic period and posterior wall thickness (PWT), relative wall thickness (RWT) and left ventricular mass index (LVMI) using ultrasound. Results: The frequencies of the AT1R gene 1166 site variant (genotypes AC and CC) and C allele in the case group for both mothers and fetuses were higher than in the control group. The IVST and PWT of mothers and fetuses and LVMI and RWT of mothers in the case group were higher than in the control group. The LVMI and RWT of mothers and IVST and RWT of fetuses with the AC or CC genotype were higher than those with the AA genotype in the case group. Conclusions: There is an association between the AT1R gene 1166 site variation and severe preeclampsia in both mothers and their fetuses. The C allele may be a predisposing factor. Remodeling of the left ventricle of severe preeclampsia has a close correlation with the AT1R gene A1166 C variation.

• 出版日期2017
• 单位新疆医科大学