Aryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms

作者：Erkin A V^*; Klaptyuk I V; Gurzhii V V; Yuzikhin O S; Krutikov V I

来源：Russian Journal of General Chemistry, 2016, 86(6): 1274-1281.

DOI：10.1134/S1070363216060098

• 2-amino-6-methylpyrimidin-4(3H)-thione
• S-alkylation
• 2-aryloxyethyl ethers
• bromination
• fungicidal activity

2-Amino-4-[(2-aryloxyethyl)sulfanyl]-6-methylpyrimidines were obtained by S-alkylation of 2-amino-6-methylpyrimidin-4(3H)-thione with 2-aryloxyethyl chlorides. Since 2-amino-4-[(2-chloroethyl)sulfanyl]-6-methylpyrimidine is prone to in situ intramolecular cyclization it cannot be used in Claisen reaction. The bromination of the target compounds provided 5-bromo derivatives; some of their hydrochlorides exhibited fungicidal activity.

• 出版日期2016-6