An efficient synthesis of quinazoline-2,4(1H,3H)-dione from CO2 and 2-aminobenzonitrile using [Hmim]OH/SiO2 as a base functionalized Supported Ionic Liquid Phase Catalyst

作者：Nale Deepak B; Saigaonkar Siddhesh D; Bhanage Bhalchandra M^*

来源：Journal of CO2 Utilization, 2014, 8: 67-73.

DOI：10.1016/j.jcou.2014.08.001

• Carbon dioxide
• Base functionalized supported ionic liquid
• phase catalysis
• Heterogeneous catalyst
• 2-Aminobenzonotrile
• Quinazoline-2,4(1H,3H)-diones

A simple base functionalized Supported Ionic Liquid Phase Catalyst using 1-hexy1-3-methyl imidazolium hydroxide ionic liquid supported on silica, (11-Imim1OH/SiO2) was used as an efficient, heterogeneous catalyst for the synthesis of quinazoline-2,4(1H,3H)-diones motif through the carboxylative coupling of CO2 with 2-aminobenzonitriles. The reactions give good to excellent yield under optimized reaction condition. The catalyst, [Hmim]OH/SiO2, was synthesized by physical adsorption phenomenon and was characterized by different techniques such as FT-IR and BET (Brunauer-Emmett-Teller) surface area analysis. The influences of different reaction parameters such as catalyst loading, reaction time, solvent, temperature and pressure on the reaction system were investigated. The developed methodology described a simple one step approach for the synthesis of a wide variety of substituted quinazoline-2,4(1H,3H)-diones with excellent yield of a desired products. Furthermore, the catalytic system was found to be recyclable up to four consecutive cycles with marginal decrease in yield after third recycle.

• 出版日期2014-12