A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate

作者:Du, Yi-Ling; He, Hai-Yan; Higgins, Melanie A.; Ryan, Katherine S.*
来源:Nature Chemical Biology, 2017, 13(8): 836-+.
DOI:10.1038/nchembio.2411

摘要

Molecules containing a nitrogen-nitrogen (N-N) linkage have a variety of structures and biological activities; however, no enzyme has yet been demonstrated to catalyze N-N bond formation in an organic molecule. Here we report that the heme-dependent enzyme KtzT from Kutzneria sp. 744 catalyzes N-N bond formation in the biosynthesis of piperazate, a building block for nonribosomal peptides.